Digital next-generation sequencing of cell-free DNA for pancreatic cancer.

Shinichi TakanoMitsuharu FukasawaHiroko ShindoEi TakahashiYoshimitsu FukasawaSatoshi KawakamiHiroshi HayakawaNatsuhiko KuratomiMakoto KadokuraShinya MaekawaNobuyuki Enomoto

Published in: JGH open : an open access journal of gastroenterology and hepatology (2021)

dNGS of cfDNA using MBs is useful for accurate detection of gene alterations even with low levels of MAFs. These results may be used to inform the development of diagnostics and therapeutics that can improve the prognosis of pancreatic cancer.

Keyphrases

copy number
genome wide
small molecule
high resolution
real time pcr
dna methylation
gene expression
mass spectrometry