Roflumilast reverses CFTR-mediated ion transport dysfunction in cigarette smoke-exposed mice.

S Vamsee RajuLawrence RasmussenPeter A SloaneLi Ping TangEmily Falk LibbySteven M Rowe

Published in: Respiratory research (2017)

Roflumilast effectively rescues CFTR-mediated chloride transport in vivo, further implicating CFTR activation as a mechanism through which roflumilast benefits patients with bronchitis.

Keyphrases

cystic fibrosis
oxidative stress
mouse model
type diabetes
adipose tissue