Cytisine-like alkaloids from the seeds of Ormosia hosiei Hemsl. et Wils.

Two new cytisine-like alkaloids, hositisines C ( 1 ) and D ( 2 ), were isolated from the seeds of Ormosia hosiei along with four known compounds, (-)-tinctorine ( 3 ), β -adenosine ( 4 ), 2'-deoxyadenosine ( 5 ), and 7, 2', 4'-trihydroxy-5-methoxyisoflavanone ( 6 ). Their structures were established using extensive spectroscopic techniques (UV, IR, CD, HRESIMS, 1 D and 2 D NMR). In the cytotoxic activity, compounds 1 - 3 and 5-fluorouracil (positive control) displayed inhibitory effects against HepG2 cells, exhibiting IC 50 values of 44.52 ± 7.83 μM, 111.49 ± 12.76 μM, 127.72 ± 18.67 μM, and 16.37 ± 3.82 μM.