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Neutron scattering in the biological sciences: progress and prospects.

Rana AshkarHassina Z BilheuxHeloísa Nunes BordalloRobert BriberDavid J E CallawayXiaolin ChengXiang-Qiang ChuJoseph E CurtisMark DadmunPaul W FenimoreDavid FushmanFrank GabelKushol GuptaFrederick HerberleFrank HeinrichLiang HongJohn KatsarasZvi KelmanEugenia KharlampievaGerald R KnellerAndrey KovalevskySusan KruegerPaul LanganRaquel L LiebermanYun LiuMathias LoscheEdward LymanYimin MaoJohn MarinoCarla MattosFlora MeilleurPeter MoodyJonathan D NickelsWilliam B O'DellHugh O'NeillUrsula Perez-SalasJudith PetersLoukas PetridisAlexei P SokolovChristopher B StanleyNorman J WagnerMichael WeinrichKevin L WeissTroy WymoreYang ZhangJeremy C Smith
Published in: Acta crystallographica. Section D, Structural biology (2018)
The scattering of neutrons can be used to provide information on the structure and dynamics of biological systems on multiple length and time scales. Pursuant to a National Science Foundation-funded workshop in February 2018, recent developments in this field are reviewed here, as well as future prospects that can be expected given recent advances in sources, instrumentation and computational power and methods. Crystallography, solution scattering, dynamics, membranes, labeling and imaging are examined. For the extraction of maximum information, the incorporation of judicious specific deuterium labeling, the integration of several types of experiment, and interpretation using high-performance computer simulation models are often found to be particularly powerful.
Keyphrases
  • current status
  • high resolution
  • health information
  • public health
  • deep learning
  • drinking water
  • quality improvement
  • fluorescence imaging