Merging Visible-Light Photocatalysis and Transition-Metal Catalysis in Three-Component Alkyl-Fluorination of Olefins with a Fluoride Ion.

The light-induced, Ru-catalyzed three-component alkyl-fluorination of olefins under mild reaction conditions is reported. This carbofluorination reaction features a wide substrate scope and good functional group tolerance. A key advantage of this photoredox reaction is the use of nucleophilic fluoride and generic alkyl groups. Late-stage functionalizations are achieved, and a copper-assisted oxidative quenching mechanism is proposed based on the mechanistic studies.