Inhibition of skeletal muscle Lands cycle ameliorates weakness induced by physical inactivity.

Justin L ShahtoutHiroaki EshimaPatrick J FerraraJ Alan MaschekJames E CoxMicah J DrummondKatsuhiko Funai

Published in: bioRxiv : the preprint server for biology (2023)

Our findings demonstrate that attenuation of muscle LOOH is sufficient to restore skeletal muscle function, in particular a protection from reduction in muscle specific force. Thus, muscle LOOH contributes to atrophy and weakness induced by HU in mice.

Keyphrases

skeletal muscle
insulin resistance
physical activity
high fat diet induced
mental health
mouse model
type diabetes
single molecule