Second Heart Field-Derived Cells Contribute to Angiotensin II-Mediated Ascending Aortopathies.
Hisashi Sawada (澤田悠)Yuriko KatsumataHideyuki HigashiChen ZhangYanming LiStephanie MorganLang Ho LeeSasha A SinghJeff Z ChenMichael K FranklinJessica J MoorleghenDeborah A HowattDebra L RateriYing H ShenScott A LeMaireMasanori AikawaMark W MajeskyHong S Lu (吕红)Alan DaughertyPublished in: Circulation (2022)
SHF-derived cells exert a critical role in maintaining vascular integrity through LRP1 and transforming growth factor-β signaling associated with increases of aortic PAI1.
Keyphrases
- angiotensin ii
- transforming growth factor
- induced apoptosis
- cell cycle arrest
- epithelial mesenchymal transition
- angiotensin converting enzyme
- heart failure
- vascular smooth muscle cells
- pulmonary artery
- endoplasmic reticulum stress
- aortic valve
- left ventricular
- cell proliferation
- pulmonary hypertension
- pulmonary arterial hypertension