Isolation of single circulating trophoblasts from maternal circulation for noninvasive fetal copy number variant (CNV) profiling.

Anna DoffiniClaudio ForcatoChiara ManganoDebora LattuadaRoberta AversaChiara MarantaEmilia D GiovannoneGenny BusonChiara BolognesiRebecca MaiocchiMartina DoriLiyana JamalRaidah B AhmadGeorge S H YeoTai Wai YeoSilvia SaragozzaRosamaria SilipigniMarta SerafiniAndrea BiondiSofia PeregoPatrizia VerganiEnrico FerrazziPaola Ricciardi-CastagnoliThomas J MusciFrancesca Romana Grati

Published in: Prenatal diagnosis (2022)

Our semi-automated methodology for the isolation and single cell analysis of cEVTS supports the feasibility of a cell-based noninvasive prenatal test for fetal genomic profiling. This article is protected by copyright. All rights reserved.

Keyphrases

single cell
copy number
mitochondrial dna
rna seq
high throughput
genome wide
dna methylation
pregnant women
machine learning
deep learning
birth weight
pregnancy outcomes
gene expression
stem cells
mesenchymal stem cells
body mass index
physical activity
cell therapy