Thyroid hormone receptor alpha modulates fibrogenesis in hepatic stellate cells.
Paul MankaJason D CoombesSvenja SydorMarzena K Swiderska-SynJan BestKarine GauthierLeo A van GrunsvenYe H OoCindy WangAnna M DiehlGeorg Sebastian HönesLars C MoellerAnja FiggeRené J BoosmanKlaas N FaberAndrea TannapfelOliver GoetzePatricia AspichuetaChristian M LangePeter LemmerWing-Kin SynPublished in: Liver international : official journal of the International Association for the Study of the Liver (2023)
These observations indicate that TH action in non-parenchymal cells is highly relevant. The interaction of TRα with TH regulates the phenotype of HSC via the TGFβ signalling pathway. Thus, the TH-TR axis may be a valuable target for future therapy of liver fibrosis.