The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation.
Andrea HildebrandtMirko BrüggemannCornelia RückléSusan BoernerJan B HeidelbergerAnke BuschHeike HänelAndrea VoigtMartin M MöckelStefanie EbersbergerAnica ScholzAnnabelle DoldTobias SchmidIngo EbersbergerJean-Yves RoignantKathi ZarnackJulian KönigPetra BeliPublished in: Genome biology (2019)
We propose that MKRN1 mediates the recognition of poly(A) tails to prevent the production of erroneous proteins from prematurely polyadenylated transcripts, thereby maintaining proteome integrity.