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The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation.

Andrea HildebrandtMirko BrüggemannCornelia RückléSusan BoernerJan B HeidelbergerAnke BuschHeike HänelAndrea VoigtMartin M MöckelStefanie EbersbergerAnica ScholzAnnabelle DoldTobias SchmidIngo EbersbergerJean-Yves RoignantKathi ZarnackJulian KönigPetra Beli
Published in: Genome biology (2019)
We propose that MKRN1 mediates the recognition of poly(A) tails to prevent the production of erroneous proteins from prematurely polyadenylated transcripts, thereby maintaining proteome integrity.
Keyphrases
  • quality control
  • dna binding
  • binding protein
  • transcription factor