The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation.

Andrea HildebrandtMirko BrüggemannCornelia RückléSusan BoernerJan B HeidelbergerAnke BuschHeike HänelAndrea VoigtMartin M MöckelStefanie EbersbergerAnica ScholzAnnabelle DoldTobias SchmidIngo EbersbergerJean-Yves RoignantKathi ZarnackJulian KönigPetra Beli

Published in: Genome biology (2019)

We propose that MKRN1 mediates the recognition of poly(A) tails to prevent the production of erroneous proteins from prematurely polyadenylated transcripts, thereby maintaining proteome integrity.

Keyphrases

quality control
dna binding
binding protein
transcription factor