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The First Casbane Hydroperoxides EBC-304 and EBC-320 from the Australian Rainforest.

Lidiya A MaslovskayaAndrei I SavchenkoVictoria A GordonPaul W ReddellCarly J PiercePeter G ParsonsCraig M Williams
Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2016)
Investigation of the Australian rainforest plant Croton insularis led to isolation of the first casbane hydroperoxide diterpenes EBC-304 and EBC-320. Extensive DFT and electronic circular dichroism (ECD) calculations in combination with 2D NMR spectroscopy determined the absolute configurations. EBC-304 and EBC-320 both display significant cytotoxicity.
Keyphrases
  • density functional theory
  • molecular dynamics
  • molecular dynamics simulations
  • molecular docking