Forced treadmill running reduces systemic inflammation yet worsens upper limb discomfort in a rat model of work-related musculoskeletal disorders.

Tianqi Tenchi Gao SmithAnn E Barr-GillespieDavid M KlyneMichelle Y HarrisMamta AminRyan W PaulGeneva E CruzHuaqing ZhaoSean GallagherMary F Barbe

Published in: BMC musculoskeletal disorders (2020)

Treadmill running was associated with lower systemic inflammation and moderate tendinosis, yet higher median nerve inflammation/fibrosis and worse task performance and sensorimotor behaviors. Continued loading of the injured tissues in addition to stress-related factors associated with forced running/exercise likely contributed to our findings.

Keyphrases

high intensity
upper limb
resistance training
oxidative stress
gene expression
physical activity
drug induced
stress induced