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Identification of therapeutic targets from genetic association studies using hierarchical component analysis.

Hao-Chih LeeOsamu IchikawaBenjamin S GlicksbergAparna A DivaraniyaChristine E BeckerPankaj AgarwalJoel T Dudley
Published in: BioData mining (2020)
We tested genome-wide associations of four disease phenotypes, including age-related macular degeneration, Crohn's disease, ulcerative colitis and rheumatoid arthritis, and demonstrated the proposed method could select more functional genes than S-PrediXcan, the previous single-step model for predicting gene-level associations from SNP-level associations.
Keyphrases
  • genome wide
  • dna methylation
  • age related macular degeneration
  • copy number
  • rheumatoid arthritis
  • ulcerative colitis
  • genome wide identification
  • gene expression
  • case control
  • genetic diversity