Palmitic acid stimulates interleukin-8 via the TLR4/NF-κB/ROS pathway and induces mitochondrial dysfunction in bovine oviduct epithelial cells.
Ayaka OhtsuHazuki TanakaKotomi SenoHisataka IwataTakehito KuwayamaKoumei ShirasunaPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2017)
We suggest that bovine OECs recognize an excessive increase in endogenous and sterile danger signals, such as PA, which may contribute to chronic oviductal inflammation, resulting in infertility associated with oviductal dysfunction.