Pharmacokinetic Evaluation by Modeling and Simulation Analysis of a Donepezil Patch Formulation in Healthy Male Volunteers.
Seok Kyu YoonKyun-Seop BaeDong Hyun HongSeong Su KimYoung Kweon ChoiHyeong-Seok LimPublished in: Drug design, development and therapy (2020)
PK simulations based on the chosen PK models suggested that, overall, donepezil exposure in plasma is similar whether with 10 mg of oral donepezil every 24 h or a 175 mg patch every 72 h, and likewise with 5 mg of oral donepezil every 24 h or an 87.5 mg patch every 72 h.
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