Probucol promotes high glucose-induced proliferation and inhibits apoptosis by reducing reactive oxygen species generation in Müller cells.
Xuxia ZhouShiBei AiZhong-Ping ChenChenXiang LiPublished in: International ophthalmology (2019)
Probucol could inhibit intracellular ROS generation, promote proliferation, and decrease apoptosis of human retinal Müller cells cultured in high glucose. This might also be associated with Keap1/Nrf2/ARE oxidative stress signaling pathway activation.
Keyphrases
- high glucose
- endothelial cells
- induced apoptosis
- oxidative stress
- cell cycle arrest
- signaling pathway
- pi k akt
- endoplasmic reticulum stress
- reactive oxygen species
- cell death
- diabetic rats
- dna damage
- epithelial mesenchymal transition
- ischemia reperfusion injury
- optical coherence tomography
- small molecule
- heat shock
- heat shock protein