Shared genetic architecture of cortical thickness alterations in major depressive disorder and schizophrenia.

He WangQiyu ZhaoYijing ZhangJuanwei MaMinghuan LeiZhihui ZhangHui XueJiawei LiuZuhao SunJinglei XuYing ZhaiYing WangMengjing CaiWenshuang ZhuFeng Liu

Published in: Progress in neuro-psychopharmacology & biological psychiatry (2024)

This study revealed the shared genetic architecture underlying cortical thickness alterations in MDD and SCZ, providing insights into common neurobiological pathways. The identified genes and pathways may serve as potential transdiagnostic markers, informing precision medicine approaches in psychiatric care.

Keyphrases

major depressive disorder
bipolar disorder
genome wide
optical coherence tomography
healthcare
copy number
mental health
palliative care
dna methylation
gene expression
transcription factor