Argatroban Anticoagulation for Adult Extracorporeal Membrane Oxygenation: A Systematic Review.
Janos GeliMassimo CapocciaDirk M MaybauerMarc O MaybauerPublished in: Journal of intensive care medicine (2021)
Argatroban infusion rates and anticoagulation target ranges showed substantial variations. The rational for divergent dosing and monitoring approaches are discussed in this paper. Argatroban appears to be a potential alternative to UFH in patients requiring ECMO. To definitively establish its safety, efficacy and ideal dosing strategy, larger prospective studies on well-defined patient populations are warranted.
Keyphrases
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- end stage renal disease
- atrial fibrillation
- respiratory failure
- venous thromboembolism
- newly diagnosed
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- low dose
- case report
- mechanical ventilation
- patient reported outcomes
- young adults
- genetic diversity