SERPINE1 and MTHFR genetic variants in patients with embolic stroke of undetermined source: links with fibrin clot properties.

Adrianna Klajmon Michał Tomasz Ząbczyk Anetta Undas Joanna Natorska

Published in: Neurologia i neurochirurgia polska (2024)

The SERPINE1 c.-820G (4_5) variants carriers have increased FVIII levels, while the SERPINE1 c.-820G (4_5) mutant homozygotes coexisting with MTHFR c.665C > T have more prothrombotic fibrin clot features and elevated Lp(a). Our study underlines the cumulative effect of genetic risk factors in patients with ESUS that might require specific antithrombotic therapy.

Keyphrases

risk factors
atrial fibrillation
copy number
genome wide
platelet rich plasma
replacement therapy