Ovarian cancer ascites induces skeletal muscle wasting in vitro and reflects sarcopenia in patients.
Jorne UbachsWouter R P H van de WorpRianne D W VaesKenneth PasmansRamon C LangenRuth C R MeexAnnemarie A J H M van BijnenSandrina LambrechtsToon Van GorpRoy F P M KruitwagenSteven W M Olde DaminkSander S RensenPublished in: Journal of cachexia, sarcopenia and muscle (2021)
Ascites of sarcopenic ovarian cancer patients induces pronounced skeletal muscle protein metabolism changes in C2C12 cells that correlate with clinical muscle measures of the patient and that are characteristic of cachexia. The use of ascites offers a new experimental tool to study the impact of both tumour-derived and systemic factors in various cachexia model systems, enabling identification of novel drivers of tissue wasting in ovarian cancer.