Sequential Intravenous-Oral Therapy for Pediatric Streptococcus anginosus Intracranial Infections.

Levofloxacin-based oral regimens were effective and well tolerated. Patients with less severe infections were more likely to be transitioned early to oral therapy. Criteria for transitioning patients to oral antibiotics for intracranial infections should be established to minimize risks inherent with central catheters.