Genome-wide Association Study for Acute Kidney Injury.

Pavan K BhatrajuIan B StanawayMelody R PalmerRajasree MenonJennifer A Schaub Steven MenezAnand SrivastavaF Perry WilsonKrzysztof KirylukSusan T Crowley Abhijit S NaikSana S SakrGail P JarvikChirag R ParikhLorraine B WareT Alp IkizlerEdward D SiewVernon M ChinchilliSteve G CocaAmit X GargAlan S GoJames S KaufmanPaul L KimmelJonathan HimmelfarbMark M Wurfel

Published in: Kidney360 (2023)

AKI is a heterogeneous clinical syndrome with various underlying risk factors, etiologies and pathophysiology that may limit the identification of genetic variants. While no variants reached genome wide significance, we report two variants in the intergenic region between DISP1 and TLR5, suggesting this region as a novel risk for AKI susceptibility.

Keyphrases

acute kidney injury
genome wide association study
copy number
genome wide
cardiac surgery
risk factors
dna methylation
toll like receptor
inflammatory response
immune response
case report
gene expression
bioinformatics analysis
nuclear factor