Pharmacological targeting PTK6 inhibits the JAK2/STAT3 sustained stemness and reverses chemoresistance of colorectal cancer.

Chaoqun LiuZhihua PanQian ChenZetao ChenWeiwei LiuLing WuMuhong JiangWandie LinYujie ZhangWeihao LinRui ZhouLiang Zhao

Published in: Journal of experimental & clinical cancer research : CR (2021)

PTK6 interacts with JAK2 and phosphorylates it to activate JAK2/STAT3 signaling to promote the stemness and chemoresistance of CRC cells. Pharmacological inhibition of PTK6 by small molecule inhibitor dramatically enhances the sensitivity to chemotherapy in nude mice and PDX models.

Keyphrases

small molecule
cancer stem cells
stem cells
induced apoptosis
epithelial mesenchymal transition
cell cycle arrest
endoplasmic reticulum stress
high fat diet induced
signaling pathway
cancer therapy
cell death
oxidative stress
binding protein
metabolic syndrome
cell proliferation
rectal cancer