P2Y12 inhibitor use predicts hematoma expansion in patients with intracerebral hemorrhage.
Ethan J HouskampYuzhe LiuJuliana Silva Pinheiro do NascimentoBabak S JahromiPaul F LindholmHau C KwaanAndrew M NaidechPublished in: Annals of clinical and translational neurology (2024)
Patients taking a P2Y12 inhibitor had more HE and less P2Y12 activity. The effect was most pronounced in patients on DAPT, suggesting a synergistic effect of P2Y12 inhibitors and aspirin with respect to HE. Acute reversal of P2Y12 inhibitors in acute ICH requires further study.
Keyphrases
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- liver failure
- prognostic factors
- type diabetes
- brain injury
- intensive care unit
- respiratory failure
- antiplatelet therapy
- acute coronary syndrome
- hepatitis b virus
- aortic dissection
- percutaneous coronary intervention
- mechanical ventilation