Left-hemispheric predominance of nigrostriatal deficit in isolated REM sleep behavior disorder.
Alex IranzoAmbra StefaniAida Niñerola-BaizanHeike StoknerMonica SerradellDolores VilasEvi HolzknechtCarles GaigJavier PaviaFrancesc LomeñaDavid ReyesKlaus SeppiJoan SantamariaBirgit HöglEduard TolosaWerner Poewenull nullPublished in: Neurology (2020)
Right-handed patients with IRBD exhibit left-hemispheric predominance of subclinical nigrostriatal dysfunction. In premotor PD, the neurodegenerative process begins asymmetrically, initially impairing the nigrostriatal system of the dominant hemisphere.