APOE2 Exacerbates TDP-43 Related Toxicity in the Absence of Alzheimer Pathology.
Axel D MenesesShunsuke KogaZonghua LiJustin O'LearyFuyao LiKai ChenAya MurakamiWenhui QiaoAishe KurtiMichael G HeckmanLaunia WhiteManling XieYixing ChenNicole A FinchMelina J LimMarion DelenclosMichael A DeTureCynthia LinaresNicholas B MartinTadafumi C IkezuMarka M van BlitterswijkLong-Jun WuPamela J McLeanRosa RademakersOwen A RossGourisankar GhoshGuojun BuNa ZhaoPublished in: Annals of neurology (2022)
Our data suggest a genotype-specific effect of APOE on TDP-43 proteinopathy and neurodegeneration in the absence of AD pathology, with the strongest association seen with APOE2. ANN NEUROL 2023.