Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting.

Lukas ZandersMelanie KnyAlexander HahnSibylle SchmidtSebastian WundersitzMihail TodirasInes LahmannArnab BandyopadhyayTobias WollersheimLars KaderaliFriedrich C LuftCarmen BirchmeierSteffen Weber-CarstensJens Fielitz

Published in: Journal of cachexia, sarcopenia and muscle (2021)

IL-6 via the gp130/JAK2/STAT3-pathway mediates sepsis-induced muscle atrophy possibly contributing to ICUAW.

Keyphrases

septic shock
acute kidney injury
skeletal muscle
intensive care unit
high glucose
diabetic rats
drug induced
endothelial cells
stress induced