Incidence of Medication-Related Osteonecrosis of the Jaw in Patients With Breast Cancer During a 20-Year Follow-Up: A Population-Based Multicenter Retrospective Study.

Christine BrunnerMarjan ArvandiChristian Marth Daniel EgleFlorentina BaumgartMiriam EmmelheinzBenjamin WalchJohanna LercherClaudia IannettiEwald WöllAgnes PechlanerAugust ZaberniggBirgit VolggerMaria CastellanOliver Tibor AndraschofskyAlice MarklMichael HubalekMichael SchnallingerSibylle PuntscherUwe SiebertSebastian SchönherrLukas ForerEmanuel BruckmoserJohannes Laimer

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)

MRONJ incidence in breast cancer patients with bone metastases was found to be considerably higher, especially for patients receiving denosumab, when compared with available data in the literature. Additionally, patients treated with denosumab developed MRONJ significantly earlier.

Keyphrases

bone mineral density
risk factors
giant cell
systematic review
healthcare
postmenopausal women
big data
emergency department
adverse drug
machine learning
double blind
artificial intelligence