KRAS status is related to histological phenotype in gastric cancer: results from a large multicentre study.

Lindsay C HewittYuichi SaitoTan WangYoko MatsudaJan OostingArnaldo N S SilvaHayley L SlaneyVeerle MelotteGordon HutchinsPatrick TanTakaki YoshikawaTomio AraiHeike I Grabsch

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2019)

This is the largest GC study investigating KRAS status and histological phenotype. We identified a relationship between KRASmut and mucinous phenotype. The high level of intratumour morphological heterogeneity could reflect KRASmut heterogeneity, which may explain the failure of anti-EGFR therapy in GC.

Keyphrases

single cell
small cell lung cancer
wild type
epidermal growth factor receptor
tyrosine kinase
gas chromatography
low grade
stem cells
bone marrow
mass spectrometry
smoking cessation