Epigenetic Regulation of Cardiomyocyte Maturation by Arginine Methyltransferase CARM1.

Tiffany A GarbuttZhenhua WangHao Fei Wang Hong MaHongmei RuanYanhan DongYifang XieLianmei TanRanan PhookanJoy A StoufferVasanth Vedantham Yuchen Yang Li Qian Jiandong Liu

Published in: Circulation (2024)

This study establishes a critical and multifaceted role for CARM1 in regulating cardiomyocyte maturation and demonstrates that deregulation of CARM1-dependent cardiomyocyte maturation gene expression may contribute to human heart diseases.

Keyphrases

gene expression
angiotensin ii
endothelial cells
high glucose
dna methylation
heart failure
nitric oxide
atrial fibrillation