A novel role of angiotensin II in epidermal cell lineage determination: Angiotensin II promotes the differentiation of mesenchymal stem cells into keratinocytes through the p38 MAPK, JNK and JAK2 signalling pathways.
Xiao JiangFan WuYuan XuJian-Xin YanYin-Di WuSheng-Hong LiXuan LiaoJun-Xian LiangZe-Hua LiHong-Wei LiuPublished in: Experimental dermatology (2020)
Our data demonstrated for the first time that Ang II plays a promotive role in the differentiation of BM-MSC into keratinocytes through the AT1 receptor, and that the p38 MAPK, JNK and JAK2 signalling pathways are involved in this process.
Keyphrases
- angiotensin ii
- mesenchymal stem cells
- angiotensin converting enzyme
- vascular smooth muscle cells
- single cell
- wound healing
- signaling pathway
- cell death
- cell therapy
- induced apoptosis
- big data
- solid phase extraction
- stem cells
- machine learning
- endoplasmic reticulum stress
- deep learning
- mass spectrometry
- binding protein
- artificial intelligence