Real-World Experience of Methotrexate in the Treatment of Skin Diseases: an Italian Delphi Consensus.

Giovanni DamianiPaolo AmerioFederico BardazziCarlo G CarreraAndrea ContiFrancesco CusanoPaolo DapavoClara DeSimoneMay El HachemGabriella FabbrociniPaolo GisondiFrancesco LoconsoleGiuseppe MicaliIria NeriAurora ParodiStefano PiasericoMarco RomanelliLuca Stingeninull nullPaolo D M Pigatto

Published in: Dermatology and therapy (2023)

In order to optimize methotrexate efficacy, it is essential to optimize treatment using appropriate dosages, carrying out a rapid drug-based step-up on a treat-to-target strategy and preferably using the subcutaneous formulation. To manage safety aspects appropriately, it is essential to evaluate patients' risk factors and carry out proper monitoring during the course of treatment.

Keyphrases

risk factors
end stage renal disease
chronic kidney disease
drug delivery
peritoneal dialysis
newly diagnosed
combination therapy
patient reported outcomes
prognostic factors
sensitive detection