Plasmodium falciparum genetic variation of var2csa in the Democratic Republic of the Congo.

Robert J VerityNicholas J HathawayAndreea WaltmannStephanie M DoctorOliver J WatsonJaymin C PatelKashamuka MwandagalirwaAntoinette K TshefuJeffrey A BaileyAzra C GhaniJonathan J JulianoSteven R Meshnick

Published in: Malaria journal (2018)

Results suggest that the DRC fits within the global pattern of high var2csa diversity and little genetic differentiation between regions. A broad multivalent VAR2CSA vaccine candidate could benefit from targeting stable regions and common variants to address the substantial genetic diversity.

Keyphrases

genetic diversity
plasmodium falciparum
copy number
genome wide
cancer therapy
gene expression