MEK5-ERK5 Axis Promotes Self-renewal and Tumorigenicity of Glioma Stem Cells.

Kazuya Fukasawa Jiajun Lyu Takuya Kubo Yuki Tanaka Akane Suzuki Tetsuhiro Horie Akane Tomizawa Ryoma Osumi Sayuki Iwahashi Kazuya Tokumura Misato Murata Masaki Kobayashi Tomoki Todo Atsushi Hirao Eiichi Hinoi

Published in: Cancer research communications (2023)

In this study, we demonstrated that MEK5-ERK5-STAT3 axis plays a critical role in maintaining stemness and tumorigenicity in GSCs by using genetic, pharmacologic, and bioinformatics tools, identifying the MEK5-ERK5-STAT3 axis as a potential target for GSC-directed therapy.

Keyphrases

pi k akt
cell proliferation
stem cells
signaling pathway
epithelial mesenchymal transition
genome wide
cell therapy
copy number