[Cell cultures in assessing radioresistance of glioblastomas].
A S BelyashovaM V GalkinN A AntipinaGalina V PavlovaAndrey V GolanovPublished in: Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko (2022)
To date, no modern methods of treatment allow overcoming malignant potential of glial neoplasms and significant increase of survival. Analysis of glioblastoma radioresistance using cancer cell cultures is one of the perspective directions, as radiotherapy is standard and available treatment method for these neoplasms. This review summarizes current studies identifying many factors of radioresistance of glial tumors, such as hypoxia, microenvironment and metabolic features of tumor, stem cells, internal heterogeneity of tumor, microRNA, features of cell cycle, DNA damage and reparation. We obtained data on involvement of various molecular pathways in development of radioresistance such as MEK/ERK, c-MYC, PI3K/Akt, PTEN, Wnt, JAK/STAT, Notch, etc. Changes in activity of RAD51 APC, FZD1, LEF1, TCF4, WISP1, p53 and many others are determined in radioresistant cells. Further study of radioresistance pathways will allow development of specific target aptamers and inhibitors.
Keyphrases
- pi k akt
- cell proliferation
- cell cycle
- cell cycle arrest
- stem cells
- signaling pathway
- dna damage
- dna damage response
- cancer stem cells
- induced apoptosis
- dna repair
- single cell
- radiation therapy
- cell therapy
- squamous cell carcinoma
- combination therapy
- cell death
- machine learning
- locally advanced
- single molecule
- big data
- deep learning
- human health
- rectal cancer