Initial Evaluation of AF78: a Rationally Designed Fluorine-18-Labelled PET Radiotracer Targeting Norepinephrine Transporter.

Xinyu ChenAlexander FritzRudolf A WernerNaoko NoseYusuke YagiHiroyuki KimuraSteven P RoweKazuhiro KoshinoMichael DeckerTakahiro Higuchi

Published in: Molecular imaging and biology (2021)

The new PET radiotracer [18F]AF78 demonstrated high affinity for NET and favourable biodistribution in rats. A structure-activity relationship between radiotracer structures and affinity for NET was revealed, which may serve as the basis for the further design of NET targeting radiotracers with favourable features.

Keyphrases

pet imaging
positron emission tomography
atrial fibrillation
cancer therapy
computed tomography
pet ct
drug delivery
mass spectrometry
iron oxide nanoparticles