DNA origami nanocalipers for pH sensing at the nanoscale.

Xinyue ZhangLi PanRuiyan GuoYueyue ZhangFan LiMin LiJiang LiJiye ShiFeng-Li Qu Xiaolei Zuo Xiuhai Mao

Published in: Chemical communications (Cambridge, England) (2022)

A DNA origami nanocaliper is employed as a shape-resolved nanomechanical device, with pH-responsive triplex DNA integrated into the two arms. The shape transition of the nanocaliper results in a subtle difference depending on the local pH that is visible via TEM imaging, demonstrating the potential of these nanocalipers to act as a universal platform for pH sensing at the nanoscale.

Keyphrases

atomic force microscopy
single molecule
circulating tumor
cell free
high resolution
high throughput
mass spectrometry
single cell
photodynamic therapy