Water content changes in new multiple sclerosis lesions have a minimal effect on the determination of myelin water fraction values.
Irene M VavasourKimberley L ChangAnna J E CombesSandra M MeyersShannon H KolindAlexander RauscherDavid K B LiAnthony TraboulseeAlex L MacKayCornelia LaulePublished in: Journal of neuroimaging : official journal of the American Society of Neuroimaging (2021)
MWF mirrors MWC and is able to monitor myelin in new lesions. Even after taking into account water content increases, MWC still decreased at lesion first appearance attributed to demyelination.