Evolution of aortic pressure during normal ageing: A model-based study.
Stamatia Z PagoulatouNikolaos StergiopulosPublished in: PloS one (2017)
The 1-D model of the ageing tree and heart captures faithfully and with great accuracy the central pressure evolution with ageing. The stiffening of the proximal aorta and the resulting augmentation of the forward pressure wave is the major contributor of the systolic pressure augmentation with age.