Inflammatory Cytokines Rewire the Proinsulin Interaction Network in Human Islets.
Duc T TranAnita PottekatKouta LeeMegha RaghunathanSalvatore LoguercioSaiful Anam MirAdrienne W PatonJames C PatonPeter ArvanAlexandre Rosa CamposPamela Itkin-AnsariPublished in: The Journal of clinical endocrinology and metabolism (2022)
Together, the data shed new light on mechanisms by which diabetes-associated cytokines dysregulate β-cell function. For the first time, we show that even short-term exposure to an inflammatory environment reshapes proinsulin interactions with critical chaperones and regulators of the secretory pathway.