Dual action of the cannabinoid receptor 1 ligand arachidonyl-2'-chloroethylamide on calcitonin gene-related peptide release.

Isabella Mai ChristiansenJacob C A EdvinssonPhilip V ReduchaLars EdvinssonKristian Agmund Haanes

Published in: The journal of headache and pain (2022)

Results from the present study indicate that ACEA per se does not exhibit antimigraine potential due to its dual agonistic properties, resulting in activation of both CB1 and TRPV1, and thereby inhibition and stimulation of CGRP release, respectively.

Keyphrases

copy number
neuropathic pain
spinal cord
climate change
transcription factor