Dysfunctional endothelial-derived microparticles promote inflammatory macrophage formation via NF-кB and IL-1β signal pathways.
Yanfang WangJie LiuXiaoli ChenHuimin SunSheng PengYashu KuangJingjiang PiTao ZhuangLin ZhangZuoren YuBrain TomlinsonPaul ChanYi-Han ChenYuzhen ZhangYing LiPublished in: Journal of cellular and molecular medicine (2018)
MPs might be involved in the inflammatory process in patients with ACS via NF-κB and IL-1β-dependent signals. Targeting EMP-mediated inflammatory responses may be a promising therapeutic strategy to limit the progression of disease in ACS.