Frequency and Severity of Exacerbations of COPD Associated with Future Risk of Exacerbations and Mortality: A UK Routine Health Care Data Study.
Hannah WhittakerAnnalisa RubinoHana MüllerováTamsin MorrisPrecil VargheseYang XuEnrico De NigrisJennifer Kathleen QuintPublished in: International journal of chronic obstructive pulmonary disease (2022)
Increasing number and severity of exacerbations were associated with increasing risk of subsequent exacerbations, all-cause mortality and COPD-related mortality. Even a single moderate event increases the risk of future events, illustrating that every exacerbation counts.