Intravenous lidocaine affects oxaliplatin pharmacokinetics in simultaneous infusion.
Frank G A M van HarenSandra van den HeuvelSandra RademaNielka van ErpLuuk van den BersselaarKris VissersMonique SteegersPublished in: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (2020)
Lidocaine does not affect the area under the curve of oxaliplatin, which is the most important parameter in drug interaction studies and for oxaliplatin treatment effect. The lower Cmax in the chemotherapeutic cycle with lidocaine is significant and remarkable, but with an unknown exact mechanism or clinical significance, making further research desirable.