Does the FSHB c.-211G>T polymorphism impact Sertoli cell number and the spermatogenic potential in infertile patients?

Maria SchubertSophie KaldeweyLina Pérez LanuzaHenrike KrenzMartin DugasSven BerresSabine KlieschJoachim WistubaJörg Gromoll

Published in: Andrology (2020)

The FSHB c.-211G>T polymorphism does not affect SC numbers or SCWL, thereby in principle maintaining the spermatogenic potential. The previously observed clinical phenotype for the FSHB genotype might therefore be caused by a hypo-stimulated spermatogenesis and not due to a decreased SC number.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
single cell
cell therapy
stem cells
polycystic ovary syndrome
patient reported outcomes
mesenchymal stem cells
insulin resistance
patient reported