Polygenic and multifactorial scores for pancreatic ductal adenocarcinoma risk prediction.
Alice Alessandra GaleottiManuel GentiluomoCosmeri RizzatoOfure ObazeeJohn P NeoptolemosClaudio PasqualiMichael NentwichGiulia Martina CavestroRaffaele PezzilliWilliam GreenhalfBernd HolleczekCornelia SchroederBen SchöttkerAudrius IvanauskasLaura GinocchiTimothy J KeyPéter HegyiLivia ArchibugiErika DarvasiDaniela BassoCosimo SpertiMaarten F BijlsmaGiuseppe BiscagliaViktor HlavacRenata Talar-WojnarowskaBeatrice Mohelnikova-DuchonovaThilo HackertYogesh VashistOndrej StrouhalHanneke van LaarhovenFrancesca TavanoMartin LovecekChristos DervenisFerenc IzbékiAndrea PadoanEwa Małecka-PanasEvaristo MaielloGiuseppe VanellaGabriele CapursoJakob R IzbickiGeorge E TheodoropoulosKrzysztof JamroziakVerena KatzkeRudolf KaaksAndrea MambriniIoannis S PapanikolaouRichárd SzmolaAndrea SzentesiJuozas KupcinskasSimona BursiEithne CostelloUgo BoggiAnna Caterina MilanettoStefano LandiMaria GazouliLudmila VodickovaPavel SoucekDomenica GioffredaFederica GemignaniHermann BrennerOliver StrobelMarkus BüchlerPavel VodickaSalvatore PaiellaFederico CanzianDaniele CampaPublished in: Journal of medical genetics (2020)
We found a highly significant association between a PRS and PDAC risk, which explains more than individual SNPs and is a step forward in the direction of the construction of a tool for risk stratification in the population.