Rutin mitigates acetic acid-induced ulcerative colitis: novel coloprotective mechanism.
Iman O SherifNora Hamad Al-ShaalanWalaa F AwadinPublished in: Toxicology research (2024)
Rutin could be a promising coloprotective agent against AA-induced ulcerative colitis by targeting the HMGB1/TLR4/MYD88/NF-kB signaling pathway.
Keyphrases
- ulcerative colitis
- signaling pathway
- toll like receptor
- pi k akt
- nuclear factor
- diabetic rats
- high glucose
- inflammatory response
- epithelial mesenchymal transition
- induced apoptosis
- oxidative stress
- lps induced
- immune response
- drug induced
- cell proliferation
- endothelial cells
- radiation therapy
- endoplasmic reticulum stress