Pharmacological modulation of adaptive thermogenesis: new clues for obesity management?

V A GenchiG PalmaG P SoriceR D'OriaC CaccioppoliN MarranoG BiondiI CarusoA CignarelliA NatalicchioL LaviolaFrancesco GiorginoS Perrini

Published in: Journal of endocrinological investigation (2023)

This review investigates the main molecules involved in the physiological (e.g. incretin hormones) and pharmacological (e.g. β3-adrenergic receptors agonists, thyroid receptor agonists, farnesoid X receptor agonists, glucagon-like peptide-1, and glucagon receptor agonists) modulation of adaptive thermogenesis and the signalling mechanisms involved.

Keyphrases

adipose tissue
insulin resistance
metabolic syndrome
weight loss
type diabetes
weight gain
high fat diet induced