Human Coronary Plaque T Cells Are Clonal and Cross-React to Virus and Self.
Roshni Roy ChowdhuryJessica D'AddabboXianxi HuangStefan VeizadesKoki SasagawaDavid M LouisPaul ChengJan SokolAnnie JensenAlexandria TsoVishnu ShankarBen Shogo WendelIsaac BakermanGrace LiangTiffany KoyanoRobyn FongAllison N NauThomas QuertermousJayakrishnan GopakumarRobert WirkaAndrew S LeeJack BoydYiping Joseph WooSiddhartha JaiswalYueh-Hsiu ChienCharles Kwok Fai ChanMark M DavisPatricia K NguyenPublished in: Circulation research (2022)
Taken together, these findings demonstrate that plaque T cells are clonally expanded potentially by antigen engagement, are potentially reactive to self-epitopes, and may interact with smooth muscle cells and macrophages in the plaque microenvironment.