Revealing the Roles of Keratin 8/18-Associated Signaling Proteins Involved in the Development of Hepatocellular Carcinoma.
Younglan LimNam-On KuPublished in: International journal of molecular sciences (2021)
Although hepatocellular carcinoma (HCC) is developed with various etiologies, protection of hepatocytes seems basically essential to prevent the incidence of HCC. Keratin 8 and keratin 18 (K8/K18) are cytoskeletal intermediate filament proteins that are expressed in hepatocytes. They maintain the cell shape and protect cells under stress conditions. Their protective roles in liver damage have been described in studies of mouse models, and K8/K18 mutation frequency in liver patients. Interestingly, K8/K18 bind to signaling proteins such as transcription factors and protein kinases involved in HCC development. Since K8/K18 are abundant cytoskeletal proteins, K8/K18 binding with the signaling factors can alter the availability of the factors. Herein, we discuss the potential roles of K8/K18 in HCC development.
Keyphrases
- end stage renal disease
- transcription factor
- ejection fraction
- mouse model
- newly diagnosed
- induced apoptosis
- chronic kidney disease
- stem cells
- single cell
- oxidative stress
- risk factors
- peritoneal dialysis
- cell therapy
- signaling pathway
- liver injury
- risk assessment
- patient reported outcomes
- cell proliferation
- bone marrow